BREAST.

ROLCAM · Posted: Wed Oct 10, 2007 1:18 am Post subject: BREAST.

Breast

What are breasts and what is their function?
Breast Components
Breast structure
Nipple and Areola structure and function
Breast Changes During Pregnancy
Hormonal Regulation Effect on Breasts
Vasculature of Breast

What are breasts and what is their function?

The breasts are specialized organs, which are located on the anterior chest wall. The female breast is more developed than the male breast, as their primary function is to produce milk for nutrition of the infant and baby. There are lots of glands in our breasts, which grow and develop during puberty and maturation. Female hormones such as oestrogen and progesterone are important in promoting growth and changes that occur in the breast, especially during pregnancy and the menstrual cycle.

Lying in a superficial layer of our skin above our chest muscles, the mammary glands in our breast drain via many ducts to our nipples. There is a dark, circular layer around the nipple, called the areola.

It is important for women to understand the normal anatomy and function of their breasts so that any abnormalities can be detected and treated.

Breast Components

The breast consists of:
milk glands (lobules) that produce and supply milk

special ducts that transfer milk from the milk glands (lobules) to the nipple

nipple

areola (pink/brown pigmented region surrounding the nipple)

fat

connective (fibrous) tissue

Breast structure

Female breasts are rarely symmetrical. In most cases, a breast is usually slightly larger or smaller, higher or lower or of different shape to the other side. When fully developed, the female adult breast is composed of 15-20 lobes of branching glands. These lobes are separated by bands of connective tissue, which radiate out from the nipple like spokes from the middle of a bicycle wheel. There is lots of fat tissue within the breast. The amount of fat that each person has present, determines the size of the breast. The fatty tissue gives the breast it's soft consistency.

The special glands in the breast are called tuboalveolar glands, which are modified sweat glands. Each of these glands end in a lactiferous duct (2-4mm in diameter) and opens up through a small hole onto the nipple. Deep to the areola, each duct has a dilated part called the lactiferous sinus, in which milk can accumulate and remain in the nursing mother. Cells which are important in contraction movements, called myoepithelial cells, are present in the gland and help in secreting fluids.

Nipple and Areola structure and function

The nipple and areola are the darker areas of the breast. The nipples contain no fat, hair or sweat glands. During puberty, the pigment in the nipple and areola increases and the nipple becomes more prominent. There are many smooth muscle fibres in tissues of the breast, which are specially arranged to help the nipple to become erect when stimulated.

During pregnancy, the areola enlarges and also becomes darker. Within the areola, there are; sebaceous glands, sweat glands and modified mammary glands (glands of Montgomery). These glands produce small elevations on the areola surface. The sebaceous glands enlarge during pregnancy and secretes oily material, which acts as a lubricant for the areola and nipple.

Breast Changes During Pregnancy

During pregnancy, many changes occur in the breast, to prepare for the baby and produce milk. Cells in the glands of breast tissue change shape and increase in size and number. Later in pregnancy, subsequent increases in breast size occur through cells which secrete milk products and these secretory products accumulating in the ducts. A special thick white/yellow fluid called colustrum is produced in the breast during the last few weeks of pregnancy and first few episodes of nursing. This is rich in protein and agents which protect the baby from harmful substances such as bacteria.
(Learn more about pregnancy advice.)

Hormonal Regulation Effect on Breasts

During puberty, growth and development of the breast occurs due to female hormones called oestrogens and progesterones. After this development, changes in breast tissues occurs during the ovarian cycle (period) due to hormonal fluctuations. During a woman's period, the breasts may feel swollen, tender, painful, or lumpy. Milk glands and ducts enlarge, and the breasts can retain water.

During pregnancy, oestrogen and progesterone produced by the corpus luteum (a small, temporary structure in females which develops from an ovarian follicle during the menstrual cycle) stimulate proliferation and development of the breast. Special hormones called prolactin and somatomammotrophin, which are produced during pregnancy also play a role. After delivery, the level of circulating hormones decrease. Milk secretion is stimulated by increased prolactin (in response to the baby's suckling) and adrenal cortical steroids. Oxytocin is also produced, which stimulates contraction of the myoepithelial cells in the mammary glands to eject milk for the baby.

As we get older and approach menopause, hormones like oestrogen and progesterone decrease. This induces changes in the breast glands, which start to degenerate.

Vasculature of Breast

Arteries carry oxygen rich blood from the heart to the chest wall and the breasts, whilst veins take de-oxygenated blood back to the heart.

The arterial supply of the breast is from:
Internal thoracic artery

Lateral thoracic and thoracoacromial arteries

Posterior intercostal arteries
Venous drainage of the breast is mainly through the axillary vein, and some drainage occurs through the internal thoracic veins.

Drainage of lymph (a clear fluid that travels through the body's arteries, circulates through tissues to help clean them, and then drains away through the lymphatic system) through the breast is very important, especially in metastases involving breast cancer cells. Lymph runs from the nipple, areola and lobules into a special network, which then drains to the axillary lymph noses, parasternal and subclavicular nodes.

The nerve supply of the breast is derived from the intercostal nerves. Nerves convey sensory fibres to the skin of the breast so there is sensation of the breast, and nerve fibres also run to the blood vessels and smooth muscles within the breast.

Diseases presenting with this Anatomy include:
Breast Pain
Carcinoma of the Breast
Ductal Carcinoma of the Breast (In situ (DCIS) and Invasive)
Inflammatory Carcinoma of the Breast
Lobular Carcinoma of the Breast (In situ (LCIS) and Invasive)
_________________
Roland Camilleri

Moderator

Sydney , Australia.